Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice

Recurrent epithelial erosions develop in the cornea due to prior injury or genetic predisposition. Studies of recurrent animal models allow us gain insight into how form and are resolved. While slowing corneal cell migration reducing their proliferation following treatment with mitomycin C reduce erosion formation mice after sterile debridement injury, additional factors have been identified related cytokine expression immune activation. The relationship between recruitment cells region where potential roles and/or repair remains unexplored C57BL/6 mouse model. Here, high resolution imaging corneas was performed at D1, D7, D28 dulled-blade mice. Around 50% these frank wounding. A detailed assessment revealed involvement M2 macrophages both developing early stages formation.